I actually adjusted really quickly to the Wiimote / nunchuck style, and now, I think I like it better than the old GameCube controls. I feel like I can relax better when I'm using the Wiimote because it's wireless and because it lets me spread my hands apart when I'm reclining. The Wiimote / nunchuck combo is also cool because if you want a real challenge, you can play with Wiimote in your left hand and the nunchuck in your right. I'm probably the only person in the world who would want to try using a joystick with my right hand, though.
Still, I'm having a lot of trouble grabbing opponents with the new controls, and I can't hit the B button as fast as I could with a GameCube controller. But these problems shouldn't be too hard to get around.